| ML, small lymphocytic is always diffuse. ML,SL and CLL are
indistinguishable and are almost always (>95%) of B-cell origin, expressing
CD 19; CD5 (a T-associated antigen); surface IgM and/or IgD. The malignant
cells are uniform small lymphocytes with scant cytoplasm. The nuclei are
round with clumped chromatin. Mitoses are rare. They are monoclonal for
light chains (either l or k restricted).
|